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Medical Cannabis
The content provided on this blog is intended for educational purposes only and should not be construed as medical advice. We strongly advise readers to seek guidance from a qualified healthcare professional regarding any medical concerns.
To reflect its medicinal nature rather than recreational use, we prefer the term ‘medical cannabis’ over terms such as ‘marijuana’, “grass”. or ‘dope’ which may carry negative connotations.
The opinions expressed in the blog belong to the respective authors, who are not medical professionals, and may not necessarily align with those of Lyphe Clinic. Lyphe Clinic does not endorse any specific products or services mentioned, except those provided through Lyphe Clinic.
Readers should be aware that the legality of medical cannabis varies by location, and this disclaimer may be subject to periodic updates.
Key Points
Glaucoma is a group of eye diseases that cause nerve damage and loss of vision. Glaucoma has no definitive symptoms, and most people only discover they have it during a routine eye exam. The condition is best characterised by an increase in intraocular pressure (IOP), which causes damage to the optic nerve.
Nearly 2% of the UK population over 40 suffers from this progressive condition. Glaucoma is the second leading cause of blindness, only behind the more prevalent cataract. Left untreated can lead to total blindness in the affected eyes.
Conventionally, glaucoma is treated with medication that lowers IOP. Medical cannabis gained popularity as a potential treatment thanks to a study published in the 1970s. In the study, researchers found cannabis helped lower IOP, like other medications did.
Given the need for alternative treatments, more people are turning to medical cannabis for glaucoma. Is it all just hype and medical myth? Or can medical cannabis actually help lower IOP and treat glaucoma? Let’s take a closer look at the evidence.
Glaucoma is a condition that affects the optic nerve. The optic nerve transports information from your eyes to your brain. When it becomes damaged, you may lose peripheral vision and experience blurry vision and pain in your eyes.
Glaucoma usually starts between ages 40 and 60; however, it can affect people at any age. It is the second leading cause of blindness in the world. People with glaucoma often experience no symptoms until the condition has progressed to a later stage.
The symptoms of the eye condition depend on its type:
The typical progression of open-angle glaucoma is slow, so it’s possible to have few complaints until the disease has advanced. In other words, most people with this type of glaucoma don’t realise they have it until their vision is significantly impaired.
Open-angle glaucoma usually occurs as a result of damage to the optic nerve. The optic nerve is the structure that carries information from the retina to the brain. If this area is damaged, it can lead to vision loss and even blindness.
One of the most common causes of optic nerve damage is increased intraocular eye pressure (IOP). Eye pressure measures how much the eye can focus on objects and images. Normal eye pressure ranges between 12 and 20 mmHg, but many factors can cause it to vary:
A healthcare provider can diagnose glaucoma through a comprehensive medical examination that includes the following:
The age at which the patient is diagnosed with glaucoma will depend on how quickly the condition progresses. As such, it is of utmost importance for patients to have their eyes diagnosed with glaucoma if symptoms are present. In cases of acute glaucoma, immediate treatment is necessary. Always consult with your doctor.
Glaucoma treatment options include medication, laser treatment and surgery.
Medication for glaucoma includes beta-blockers to control intraocular pressure (IOP) and medications that target ocular inflammation, such as prostaglandin analogues. Most of these medications come in an eye drop form. However, some cases require a prescribed oral medicine to bring IOP further down. Always consult with you doctor.
Possible side effects of glaucoma medication include:
In more serious cases, glaucoma can only be treated with invasive methods:
In 1970, a group of researchers published a study on the effects of cannabis on glaucoma patients. The conclusion was that smoking cannabis could reduce intraocular pressure by 25 per cent. Ever since this finding was presented, there’s been a debate about whether or not cannabis is a viable treatment for glaucoma.
Medical cannabis contains two primary cannabinoids known for their therapeutic and medicinal applications:
These cannabinoids influence the endocannabinoid system’s activity, which is responsible for regulating a wide range of physiological processes. The endocannabinoid system has receptors in the eye and other tissues that respond to the cannabinoids found in cannabis.
Medical cannabis is an increasingly popular treatment option for glaucoma. Studies have shown that cannabis may reduce intraocular pressure (IOP), which is one of the primary risk factors for developing the disease. In addition to lowering eye pressure, medical cannabis can also reduce inflammation and oxidative stress, leading to increased IOP.
There is conflicting data on the effects of cannabis on intraocular pressure. Some studies have shown that patients with glaucoma who use medical cannabis experience a reduction in eye pressure, while others show no effect.
For instance, a 2019 review published in the Diabetes & Metabolism Journal found evidence that medical cannabis may help lower IOP. However, there is only limited evidence for this effect. The authors noted that most studies were small and had methodological flaws or limitations.
In an older 2006 study published in the Journal of Glaucoma, researchers found that 5mg of THC significantly reduced IOP after two hours. The same study found that a low dose of CBD did nothing, but a higher dose (40mg) led to a small IOP increase within four hours.
One problem with THC treatment is the amount a patient needs to take to achieve the desired effect. The 2006 study found that 5mg of THC reduced IOP by only 0.3mmHg, which is not considered a clinically significant change. In other words, you would need to take quite a bit of medical cannabis to achieve any measurable benefit for glaucoma patients. The needed THC dose will disrupt daily life.
THC may reduce IOP, but also reduce the blood pressure within the optic nerve. This effect can be problematic for patients with glaucoma who already have impaired blood flow to the optic nerve.
In a 2021 study published in the International Journal of Molecular Sciences, researchers found that CBD may help treat glaucoma. CBD’s effect on eye conditions lies in its anti-inflammatory and antioxidative properties.
Inflammation and oxidative stress caused by free radicals can lead to increased IOP. The endocannabinoid system (ECS) is normally involved in regulating inflammatory responses. CBD acts on CB receptors to modulate inflammation, which can help reduce IOP.
Nevertheless, CBD may have conflicting roles in increasing or decreasing IOP. Some studies suggest that dosage matters – a high CBD dose can lead to negative outcomes. Still, it remains unclear how CBD impacts eye pressure.
Oxidative stress is a condition in which the body has too many free radicals, which can cause damage to cells. It is well known that oxidative stress can lead to eye diseases such as age-related macular degeneration (AMD) and more.
In a 2021 study published in Neuropharmacology, researchers found that CBD can help the retina against damage caused by oxidative stress. Oxidative stress is one of the main causes of glaucoma. This finding could be especially promising for people with this disease.
The authors also explain that CBD decreases inflammation and helps protect cells from free radicals. These effects may also help prevent or delay oxidative damage and other harmful effects on neural tissue.
Glutamate is an amino acid that plays an important role in the human body. It’s a neurotransmitter that helps relay messages between nerve cells, but too much of it can cause damage to your brain cells. Glutamate spillover can also increase inflammation and oxidative stress.
People with glaucoma have higher levels of glutamate in their eyes than those without the disease, which could be why CBD could be effective at treating this condition. A 2021 study published in the International Journal of Molecular Sciences suggests that CBD can help dampen the release of the neurotransmitter in brain synapses.
If you are taking other medications, talk to your doctor about whether medical cannabis is safe. Doctors generally recommend that patients avoid using cannabis with sedatives, antidepressants and opiates.
Patients with a history of psychosis should avoid medical cannabis oil that contains THC. Pregnant or breastfeeding women should not use medical cannabis.
CBD options are generally well-tolerated, even at higher doses. Still, make sure to follow the recommended dose of medical cannabis. Do not mix medical cannabis with alcohol or medications without consulting your physician first.
Lifestyle changes can also lead to an improvement in symptoms:
Other herbal remedies like bilberry extract also show promise in lowering eye pressure. Studies have also shown that a specific type of omega-3 fatty acid called EPA (eicosapentaenoic acid) can help slow the progression of glaucoma.
Medical cannabis remains a controversial treatment option for glaucoma. While cannabis may help lower IOP, many questions remain about which cannabinoid/s and how much should be administered.
THC can help reduce eye pressure. CBD can help prevent inflammation and oxidative stress. However, further research is needed to make medical cannabis oil for glaucoma treatment a viable option. Always consult with a doctor.
At Lyphe, we provide a safe and professional environment. Our team of expert doctors will help you determine if medical cannabis is right for your eye condition. Contact us today to schedule an appointment!
Medical cannabis oil may help treat glaucoma based on early clinical findings. However, the data is still conflicting, and more research is needed.
Glaucoma is a condition that cannot be reversed, but it can be managed through medication and/or surgery. If left untreated, glaucoma can lead to vision loss and blindness.
A 2018 study found that CBD oil-based eye drops elevated eye pressure in lab mice. However, the rise in eye pressure may not necessarily be dangerous as it may be controlled.
Lifestyle changes like exercising regularly and reducing stress can help reduce eye pressure. You should also eat a diet rich in omega-3 fatty acids (e.g., salmon, tuna and sardines) to keep ocular blood flow healthy.
Some evidence shows that CBD may increase intraocular pressure (IOP), which can worsen glaucoma. However, there’s also evidence that CBD may help reduce IOP in some cases.
https://www.mdpi.com/1422-0067/22/7/3798/htm
https://www.medicalnewstoday.com/articles/marijuana-and-glaucoma
https://pubmed.ncbi.nlm.nih.gov/16988594
https://dalspace.library.dal.ca/bitstream/handle/10222/78955/9830-17586-1-SM.pdf
https://www.mayoclinic.org/diseases-conditions/glaucoma
https://www.ncbi.nlm.nih.gov/books/NBK224386/
https://iovs.arvojournals.org/article.aspx?articleid=2718702
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1358964/
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