Alternatives To Opioids For Pain Relief – Natural Solutions That Show Promise

Key Points

• Opioids are strong prescription medications used to manage moderate to severe pain, but long-term use carries risks including dependence, tolerance, and serious side effects.
• Natural and non-opioid alternatives can complement or, in some cases, reduce reliance on opioids while supporting overall health.
• Medical cannabis is an evidence-backed option in the UK for some chronic pain patients under prescription.
• Other options include herbal supplements, physical therapy, vitamin B12, acupuncture, yoga, meditation, and non-invasive therapies.
• Always consult a qualified medical professional before changing or starting any treatment plan.

Introduction

Chronic pain affects millions in the UK, and opioids are often prescribed to manage it. According to the NHS, approximately 13% of adults have been prescribed an opioid at some point, and long-term use carries risks including addiction, overdose, and diminished quality of life (Priory Group, 2025).

The UK has among the highest opioid consumption rates in Europe, highlighting the need for safer, evidence-based alternatives. Recent research shows a growing interest in non-opioid and natural approaches to pain relief that reduce side effects and support patient wellbeing (NHS, Medical Cannabis).

1. Medical Cannabis

Medical cannabis, legally prescribed in the UK as cannabis-based medicinal products (CBMPs), is increasingly used to help manage chronic pain when conventional treatments are insufficient. CBMPs are available by prescription from specialist clinics like Lyphe Clinic (Lyphe Clinic – UK Medical Cannabis).

How it works

• Cannabinoids, including THC and CBD, interact with the body’s endocannabinoid system, which plays a role in regulating pain and inflammation.
• Evidence suggests some patients experience reduced pain perception, improved sleep, and enhanced quality of life when using CBMPs alongside other treatments (NICE Guidance NG144).

Opioid-sparing potential

• Research indicates that some patients reduce opioid use after starting medical cannabis under supervision.
• A systematic review found reductions of up to 64% in opioid consumption in certain chronic pain populations (NCBI, 2018).

UK Compliance Note: CBMPs are not a replacement for opioids but may be considered as part of a multidisciplinary pain management plan.

2. Herbal Supplements

Herbal supplements are natural compounds that may support pain relief and reduce inflammation:

Note: Herbal supplements should be considered complementary and not a substitute for prescribed medications.

3. Physical Therapy

• Physical therapy can strengthen muscles, improve flexibility, and reduce chronic pain.
• UK guidance recommends physiotherapy for conditions like lower back pain, fibromyalgia, and osteoarthritis (NHS – Physiotherapy).
• Studies show pain reduction of 60–70% after several weeks of structured therapy.

4. Vitamin B12 Injections

• B12 deficiency can contribute to nerve pain and fatigue.
• Intramuscular B12 injections may support nerve health and complement other pain treatments (Mayo Clinic – Vitamin B12).
• Consultation with a doctor is essential to ensure safety and appropriateness.

5. Extracorporeal Pulse Activation Technology (EPAT)

• Non-invasive therapy using sound waves to target localized musculoskeletal pain.
• Evidence suggests EPAT may reduce pain in tendinopathy, muscle strains, and joint injuries (ScienceDirect, 2018).

6. Acupuncture and Chiropractic Care

• Acupuncture: May relieve chronic pain and nausea by stimulating specific points (NHS – Acupuncture).
• Chiropractic care: Spinal manipulation can improve mobility and reduce back, neck, and headache pain. Should be performed by licensed practitioners.

7. Mind-Body Approaches

• Meditation and Yoga: Reduce stress, release endorphins, and improve pain management. Evidence supports benefits in chronic pain and mental health (NHS – Yoga and Mental Health).
• Biofeedback and Neurofeedback: Non-invasive techniques to train the nervous system to reduce pain response.

Conclusion

Chronic pain is complex, and while opioids can provide relief, long-term use carries serious risks, including addiction and overdose. The good news is that evidence-based alternatives exist. From medical cannabis and herbal supplements to physical therapy and mind-body techniques, there are options to help manage pain safely.

For patients in the UK, medical cannabis under supervision is one of the most promising opioid-sparing options, but it should always be considered within a structured, clinician-led program. Clinics like Lyphe provide guidance on integrating CBMPs with other therapies to improve quality of life.

Next Step: Speak with a qualified healthcare professional to explore which alternatives are suitable for your condition.